Hepatocellular carcinoma HCC ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy.
Liver Cancer Research Paper
Research Progresses of Targeted Therapy and Immunotherapy for Hepatocellular Carcinoma
According to data, an estimated , people in the United States will die from cancer this year, while approximately 1. Cancer is the second leading cause of death in the US and constitutes approximately 22 percent of deaths1. In addition, cancer creates huge financial burdens on both individuals and society. Research surrounding miRNAs has found that manipulation of miRNAs has led to inhibition of metastasis, and miRNAs can be used as biomarkers in the diagnosis and prognosis of cancers2. Micro-RNAs are small non-coding RNA molecules that are involved in post-transcriptional regulation of gene expression3. Much research has specifically focused on miRNA-7 and miR and their roles in cancer metastasis, as well as their functions as oncogenes or tumor suppressors in specific cancers4. Elevated expression of epidermal growth factor receptor EGFR is associated with the progression of and treatment resistance of head and neck cancer HNC.
Cancer is the first cause of death in developed countries and the second in developing countries. However, among primary liver cancer, hepatocellular carcinoma is by far the most common histological subtype. Notwithstanding the health promotion and disease prevention campaigns, more than half a million new hepatocellular carcinoma cases are reported yearly, being estimated to growth continuously until Taking this scenario under consideration and the fact that some aspects concerning hepatocellular carcinoma evolution and metastasize process are still unknown, animal models assume a crucial role to understand this disease.
This sample Liver Cancer Research Paper is published for educational and informational purposes only. If you need help writing your assignment, please use our research paper writing service and buy a paper on any topic at affordable price. Also check our tips on how to write a research paper , see the lists of health research paper topics , and browse research paper examples. Hepatic tumors may either originate in the liver — from hepatocytes, bile duct epithelium, or mesenchymal tissue — or spread to the liver from primary malignant tumors in distant or adjacent organs. Tumors originating in the liver are either malignant or benign.